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Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers  Neil E. Alexis, PhD, John.

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Presentation on theme: "Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers  Neil E. Alexis, PhD, John."— Presentation transcript:

1 Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers  Neil E. Alexis, PhD, John C. Lay, DVM, PhD, Kirby Zeman, PhD, William E. Bennett, PhD, David B. Peden, MD, MS, Joleen M. Soukup, MPH, Robert B. Devlin, PhD, Susanne Becker, PhD  Journal of Allergy and Clinical Immunology  Volume 117, Issue 6, Pages (June 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 γ-Camera image of the whole lung (left and right, stomach shown bottom quadrant left lung) immediately after a central airway deposition of radiolabeled 99mTc-SC particles for 1 subject. Outlines of the right and left lung are based on the xenon equilibrium scan. The central (C) airways are shown for both lungs. Increased brightness represents greater presence of particles. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Mean (±SEM) neutrophil (%PMN) response in induced sputum 2 to 3 hours after inhalation of saline (hatched bar), coarse fraction particulate matter (PM ; solid bar), and heat-inactivated coarse fraction particulate matter (PM2.5-10−; open bar). PM and PM2.5-10− responses were significantly (P < .05) increased versus saline (∗). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Mean (± SEM) mRNA TNF-α expression on Percoll isolated sputum macrophages 2 to 3 hours after inhalation of saline (hatched bar), coarse fraction particulate matter (PM ; solid bar), and heat-inactivated coarse fraction particulate matter (PM2.5-10−; open bar). Expression of mRNA TNF-α was significantly (P < .05) increased after PM versus saline inhalation (∗). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 Mean (± SEM) mCD14 (A), CD11b (B), and HLA-DR (C) expression (MFI) on sputum macrophages and monocytes 2 to 3 hours after inhalation of saline (hatched bar), coarse fraction particulate matter (PM ; solid bar), and heat-inactivated coarse fraction particulate matter (PM2.5-10−; open bar). A, mCD14 expression (MFI) on macrophages and monocytes was significantly (P < .05) elevated after PM versus saline (∗) and versus PM2.5-10− (#) inhalation. mCD14 was also significantly (P < .05) elevated after PM2.5-10− inhalation versus saline (∗). B, CD11b/CR3 expression (MFI) on macrophages was significantly (P < .05) elevated after PM versus saline (∗). C, HLA-DR expression (MFI) on macrophages was significantly (P < .05) elevated after PM versus saline (∗) and versus PM2.5-10− (#) inhalation. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

6 Fig 5 Mean (± SEM) phagocytosis (MFI) of IgG-opsonized Saccharomyces cerevisiae zymosan bioparticles by sputum macrophages, monocytes, and neutrophils 2 to 3 hours after inhalation of saline (hatched bar), coarse fraction particulate matter (PM ; solid bar), and heat-inactivated coarse fraction particulate matter (PM2.5-10−; open bar). Phagocytosis (MFI) was significantly (P < .05) elevated after PM versus PM2.5-10− inhalation (#). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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