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Microscopic Colitis: Clinical and Pathologic Perspectives

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Presentation on theme: "Microscopic Colitis: Clinical and Pathologic Perspectives"— Presentation transcript:

1 Microscopic Colitis: Clinical and Pathologic Perspectives
Andreas Münch, Cord Langner  Clinical Gastroenterology and Hepatology  Volume 13, Issue 2, Pages (February 2015) DOI: /j.cgh Copyright © 2015 AGA Institute Terms and Conditions

2 Figure 1 Incidence of MC in Olmsted County (1985–2011).
Figure courtesy of Darrell Pardi (Mayo Clinic). Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2015 AGA Institute Terms and Conditions

3 Figure 2 (A) LC with a significantly increased number of IELs, increased mononuclear inflammation of the lamina propria, and preserved mucosal architecture (original magnification: 100×). (B) High-power view of IELs. Note the degenerative changes of the surface epithelium (original magnification: 250×). Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2015 AGA Institute Terms and Conditions

4 Figure 3 (A) CC with an amorphous eosinophil subepithelial collagen band, approximately 30-μm thick. Note secondary degenerative changes with typical sloughing of the surface epithelium (original magnification: 100×). (B) Masson trichrome stain (original magnification: 100×) and (C) immunostaining with antibodies directed against tenascin (original magnification: 100×) show the characteristic irregular (jagged) appearance of the collagen band at the lower border. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2015 AGA Institute Terms and Conditions

5 Figure 4 Algorithm for the treatment of MC proposed by the European Microscopic Colitis Group.1 6-MP, 6 mercaptopurine. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2015 AGA Institute Terms and Conditions


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