1. Figure 2: | The p53 core domain is shown as a tetramer bound to DNA from two different rotation angles. a | Residues affected by the five most common tumour-associated missense mutations (Arg273, Arg248, Arg175, Arg245 and Arg282) according to the cBioportal database158, 159, the TP53 website24 and the International Agency for Research on Cancer (IARC) TP53 database25 are highlighted. b | Three p53 cysteine residues (Cys124, Cys182 and Cys277) that are targets for mutant-p53-reactivating compounds PRIMA-1 (Cys124) and PK11007 (Cys182 and Cys277) are highlighted. Figure adapted from RCSB PDB (PDB ID 2AC0) (Ref. 160). Data from Ref. 161.