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Non-invasive diagnosis and biomarkers in alcohol-related liver disease

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Presentation on theme: "Non-invasive diagnosis and biomarkers in alcohol-related liver disease"— Presentation transcript:

1 Non-invasive diagnosis and biomarkers in alcohol-related liver disease
Christophe Moreno, Sebastian Mueller, Gyongyi Szabo  Journal of Hepatology  Volume 70, Issue 2, Pages (February 2019) DOI: /j.jhep Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

2 Fig. 1 Factors influencing liver stiffness measurement.
Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

3 Fig. 2 Practical algorithm in patient with excessive alcohol consumption. AST, aspartate aminotransferase; HCC, hepatocellular carcinoma. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

4 Fig. 3 Influence of AST elevation on liver stiffness measurement in ALD patients. ALD, alcohol-related liver disease; AST, aspartate aminotransferase. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

5 Fig. 4 MicroRNAs as emerging biomarkers in ALD. In ALD, miR-155 expression is increased in the liver in hepatocytes and particularly in Kupffer cells and macrophages. Hepatocyte expression of miR-122 is reduced in ALD in mice. These changes in the liver occur while circulating levels of several miRNAs increase including miR-122, miR-155, miR-192 and miR-30a. Most of these miRNAs a found in the circulation packaged into exosomes and/or extracellular vesicles. ALD, alcohol-related liver disease; miRNAs, small non-coding RNAs. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions


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