1. Birgitta Maćešić, Mirica Rapić
Morbidity, mortality and utilisation of drugs for chronic obstructive airway diseases
Birgitta Maćešić, Mirica Rapić

2. Introduction Chronic obstructive airway diseases (asthma and COPD)
COPD – prevalence 4% - 10% (increasing)
COPD - the fifth cause of death (WHO)
COPD – low quality of life
COPD - absenteism and invalidity

3. Aims and purpose
To investigate morbidity and mortality trends and utilisation of anti-asthmatics in Croatia,
The obtained results might be useful in raising the awareness if anti-asthmatics drug’s utilisation is in accordance to evidence based knowledge and to forecast a future trends important for family doctors and decision makers

4. Method
Primary Health Care (PHC) morbidity data – Croatian Health-service Yearbooks, 2006 – 2015
ICD-X – respiratory - J diagnostic codes
J40 - J47 codes (asthma and COPD) – one group
Mortality data – Annual Reports of Croatian Institute for Public Health
Specific mortality – obstructive pulmonary diseases

5. Anti-asthmatic drugs utilisation data
Annual Reports of Croatian Agency for Medicinal Products and Medical Devices,
Anatomic-therapeutic clasification (ATC) index
Defenied daly doses/1000/day (DDD/TID)

6. Anti-asthmatics Respiratory – R, R03 – antiasthamtics
R03AC - Saba, Laba,
R03BA – glukocorticoids,
R03BB - anticholinergics (Sama, Lama),
R03AK - adrenergics + corticosteroids,
R03AL - adrenergics i anticholinergics,
R03DA - xanthines,
R03DC - Leukotriene receptor antagonists, R03DX - Other - omalizumab, roflumilast

7. Results
Morbidity
Drug utilisation
Mortality

8. Morbidity of chronic obstructive airway diseases (J40 – J47)

9. Total drug utilisation – R03

10. Utilisation of specific groups

11. Mortality

12. Conclusions Decreased morbidity trend Increased drug utilisation
Higher increase in the groups of: anticholinergics (R03BB) by 4,14 times; glucocorticoids (R03BA) by 2,24 times; Leukotriene receptor antagonists ( R03DC) by 1,56 times
Increased mortality trend

13. For communication
Birgitta Maćešić, bacc. med. techn., Specijalistička ordinacija obiteljske medicine “Dr. Mirica Rapić”, Karlovac
Mirica Rapić, specialist of Family Medicine, Specijalisitčka ordinacija obiteljske medicine “Dr. Mirica Rapić”, Karlovac