1. Volume 31, Issue 2, Pages 159-161 (February 2017)
Pheochromocytomas and Paragangliomas, Genetically Diverse and Minimalist, All at Once! 
Patricia L.M. Dahia 
Cancer Cell 
Volume 31, Issue 2, Pages (February 2017)
DOI: /j.ccell
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Pheochromocytoma and Paraganglioma Genetic Diversity
Genes involved in pheochromocytoma and paraganglioma, depicted by the timing of the mutation acquisition, from development through adulthood: genes listed on the left are mutated in the germline (either germ cell or zygote); genes shown in the middle are mutated postzygotically but before terminal differentiation (mosaic); and those at the right are mutated somatically in terminally differentiated chromaffin (target) cells. The blue square includes genes that display only germline mutations, orange contains genes mutated only at the somatic level, purple is a gene detected only as a mosaic, green squares list genes that can be mutated either at the germline or somatic level, and red is a gene detected either as somatic or a mosaic mutation. Mutations of these various genes are mutually exclusive in these tumors. An exception is the ATRX gene, which is mutated preferentially in tumors carrying a germline SDHB mutation.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2017 Elsevier Inc. Terms and Conditions