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Hal M. Hoffman, Fred A. Wright, David H. Broide, Alan A

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Presentation on theme: "Hal M. Hoffman, Fred A. Wright, David H. Broide, Alan A"— Presentation transcript:

1 Identification of a Locus on Chromosome 1q44 for Familial Cold Urticaria 
Hal M. Hoffman, Fred A. Wright, David H. Broide, Alan A. Wanderer, Richard D. Kolodner  The American Journal of Human Genetics  Volume 66, Issue 5, Pages (May 2000) DOI: /302874 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Multipoint linkage analysis between FCU and nine markers on chromosome 1q43-q44. Genotype information from individuals from four families was used. Genetic distances between markers are expressed in centimorgans and are calculated on the basis of the sex-averaged map of the Center for Medical Genetics - Marshfield, WI, USA. Multipoint analysis for family 1 was performed separately, because of its large size; family 1 data were combined with data from families 2, 4, and 5. The American Journal of Human Genetics  , DOI: ( /302874) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Haplotypes for nine markers from 1q43-q44 for five families with FCU. Genetically uninformative cases are not included. Marker order is shown to the left of each generation. Disease-linked haplotypes are indicated by being boxed. Key recombination events are observed between D1S423 and D1S2836 in patient 5 (family 1), between D1S1609 and D1S423 in patient 34 (family 2), and between D1S2836 and D1S2682 in patient 41 (family 2). The American Journal of Human Genetics  , DOI: ( /302874) Copyright © 2000 The American Society of Human Genetics Terms and Conditions


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