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EASL Clinical Practice Guidelines: Management of chronic hepatitis B
European Association for the Study of the Liver Journal of Hepatology Volume 50, Issue 2, Pages (February 2009) DOI: /j.jhep Copyright © Terms and Conditions
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Fig. 1 Rates of HBe seroconversion, undetectable HBV DNA and normal ALT at one year of therapy with pegylated interferon alpha-2a (PEG-IFN), lamivudine (LAM), adefovir (ADV), entecavir (ETV), telbivudine (LdT) and tenofovir (TDF) in HBeAg-positive patients with CHB in randomized clinical trials. These trials used different HBV DNA assays and they were not head-to-head comparisons for all the drugs; thus, these numbers are only indicative and should be considered with caution. Journal of Hepatology , DOI: ( /j.jhep ) Copyright © Terms and Conditions
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Fig. 2 Rates of undetectable HBV DNA and normal ALT at one year of therapy with pegylated interferon alpha-2a (PEG-IFN), lamivudine (LAM), adefovir (ADV), entecavir (ETV), telbivudine (LdT) and tenofovir (TDF) in HBeAg-negative patients with CHB in randomized clinical trials. These trials used different HBV DNA assays and they were not head-to-head comparisons for all the drugs; thus, these numbers are only indicative and should be considered with caution. Journal of Hepatology , DOI: ( /j.jhep ) Copyright © Terms and Conditions
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Fig. 3 Cumulative incidence of HBV resistance to lamivudine (LAM), adefovir (ADV), entecavir (ETV), telbivudine (LdT) and tenofovir (TDF) in published pivotal trials in NUC-naive patients. For method of calculation, see ref. [29]. These trials included different populations, used different exclusion criteria and different follow-up endpoints. Journal of Hepatology , DOI: ( /j.jhep ) Copyright © Terms and Conditions
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