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Volume 15, Issue 8, Pages (July 2016)

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Presentation on theme: "Volume 15, Issue 8, Pages (July 2016)"— Presentation transcript:

1 Volume 15, Issue 8, Pages 811-819 (July 2016)
Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study  Panagiotis Fotiadis, BS, Sanneke van Rooden, PhD, Jeroen van der Grond, PhD, Aaron Schultz, PhD, Sergi Martinez-Ramirez, MD, Eitan Auriel, MD, Yael Reijmer, PhD, Anna M van Opstal, PhD, Alison Ayres, BA, Kristin M Schwab, BA, Alzheimer's Disease Neuroimaging Initiative (ADNI), Trey Hedden, PhD, Prof Jonathan Rosand, MD, Anand Viswanathan, MD, Marieke Wermer, MD, Gisela M Terwindt, MD, Prof Reisa A Sperling, MD, Jonathan R Polimeni, PhD, Prof Keith A Johnson, MD, Prof Mark A van Buchem, MD, Prof Steven M Greenberg, MD, Dr M Edip Gurol, MD  The Lancet Neurology  Volume 15, Issue 8, Pages (July 2016) DOI: /S (16) Copyright © 2016 Elsevier Ltd Terms and Conditions

2 Figure 1 Differences in cortical thickness between patients with hereditary cerebral haemorrhage with amyloidosis–Dutch type and their age-matched controls A general linear model was computed to schematically explore the regional differences in cortical thickness between patients with HCHWA-D and healthy controls, after adjusting for age and sex. Topographic surface maps were generated using a threshold of p<0·01 (with false discovery rate correction for multiple comparisons). The resulting maps show the statistically significant regional differences in cortical thickness. CAA=cerebral amyloid angiopathy. HCHWA-D=hereditary cerebral haemorrhage with amyloidosis–Dutch type. L=left. R=right. The Lancet Neurology  , DOI: ( /S (16) ) Copyright © 2016 Elsevier Ltd Terms and Conditions

3 Figure 2 Differences in cortical thickness between patients with sporadic cerebral amyloid angiopathy and their age-matched controls A general linear model was computed to schematically explore the regional differences in cortical thickness between patients with sporadic CAA and healthy controls, after adjusting for age and sex. Topographic surface maps were generated using a threshold of p<0·01 (with false discovery rate correction for multiple comparisons). The resulting maps show the statistically significant regional differences in cortical thickness. CAA=cerebral amyloid angiopathy. L=left. R=right. The Lancet Neurology  , DOI: ( /S (16) ) Copyright © 2016 Elsevier Ltd Terms and Conditions


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