1. CASO CLINICO
Il paziente naϊve
ad alta viremia

2. Viremia: >500000 copies/ml CD4: 243 cells/µl
Risk Factor
MSM
Clinical Case: ID 7200 Patient
with HIV-1 CRF12_BF subtype
Age 45
Sex M
CDC stage B2
I Seropositivity January 2008 in
out
Feb-08
Apr-08
May-08
Jul-08
Oct-08
Jan-09
Apr-09
Jul-09
Jan-10
Apr-10
Aug-10
Nov-10
Mar-11
Jun-11
Nov-11
Mar-12
1.0
1.5
2.0
2.5
3.0
3.5
4.0
4.5
5.0
5.5
6.0
Viremia (log copies/ml) 50
100
150
200
250
300
350
400
450
500
550
600
650
700
750
800
850
900
CD4 cell count (cells/ul)
> cps/ml
Undetectability threshold
6.5
GRT February 2008
PR: L10V
RT: None
Other pol mutations
PR: K14KR, I15V, G17D, E35D, M36I, R41K, R57K, Q61N I93L
RT: V35T, V60I, K122E, D123A, I135IT, I142IT, I178IM, I195IL, G196E, A272P, T286A, I293V, E297K
On February 2008
Viremia: > copies/ml
CD4: 243 cells/µl
Rapid achievement of virological response and maintenance of undetectability in patient with very high pre-HAART viremia
FEB ‘08 – MAR ‘12
TDF+FTC, EFV

3. Clinical Case: ID 7200 Patient I Seropositivity January 2008
Risk Factor
MSM
Clinical Case: ID 7200 Patient
with HIV-1 CRF12_BF subtype
Age 45
Sex M
CDC stage B2
I Seropositivity January 2008
Mutation scoring* for the protease
PR 
ATV/r 
DRV/r 
FPV/r 
IDV/r 
LPV/r 
NFV 
SQV/r 
TPV/r 
L10V 5
Total: 
GRT March 2008
Mutation scoring* for the reverse transcriptase
RT 
3TC 
ABC 
AZT 
D4T 
DDI 
FTC 
TDF 
EFV
ETR
NVP
RPV
Total: 
GRT March 2008
* Stanford Algorithm (
Susceptible virus