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Spinal cord injury in experimental thoracic aortic occlusion: investigation of combined methods of protection  James R. Elmore, MD, Peter Gloviczki, MD,

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Presentation on theme: "Spinal cord injury in experimental thoracic aortic occlusion: investigation of combined methods of protection  James R. Elmore, MD, Peter Gloviczki, MD,"— Presentation transcript:

1 Spinal cord injury in experimental thoracic aortic occlusion: investigation of combined methods of protection  James R. Elmore, MD, Peter Gloviczki, MD, C.Michel Harper, MD, Michael J. Murray, MD, Qing Hua Wu, MD, Thomas C. Bower, MD, Peter C. Pairolero, MD, James M. Naessens, MPH, Jasper R. Daube, MD  Journal of Vascular Surgery  Volume 15, Issue 5, Pages (May 1992) DOI: / (92)90713-I Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Experimental design of a canine model of double cross-clamping the thoracic aorta and use of aortofemoral shunting. Catheter is inserted into cisterna magna to monitor pressure and drain CSF. Journal of Vascular Surgery  , DOI: ( / (92)90713-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Spinal cord blood flow in lumbar gray matter. Data expressed as median blood flow in ml/100 gm/min. Significant improvement in flows during occlusion in animals with CSF drainage or aortofemoral shunts as compared with controls. Journal of Vascular Surgery  , DOI: ( / (92)90713-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Hemodynamic pressure measurements before, during, and after thoracic aortic occlusion. Animals with aortofemoral shunts had the lowest proximal mean aortic pressures and the highest distal mean aortic pressures and spinal cord perfusion pressures. No difference in CSF pressure, in animals without CSF drainage, either with or without aortofemoral shunts. Journal of Vascular Surgery  , DOI: ( / (92)90713-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Top, Light micrograph of normal lumbar spinal cord gray matter from a dog without neurologic injury after aortic occlusion. Bottom, Light micrograph of lumbar spinal cord gray matter of paraplegic control animal. Histologically there is anterior horn cell degeneration with ischemia of surrounding neural tissue. (Hematoxylin-eosin stain; original magnification × 400.) Journal of Vascular Surgery  , DOI: ( / (92)90713-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

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