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Immunologic cross-reactivity between respiratory chemical sensitizers: Reactive dyes and cyanuric chloride  Meinir Jones, PhDa, Cynthia Graham, PhDb,

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Presentation on theme: "Immunologic cross-reactivity between respiratory chemical sensitizers: Reactive dyes and cyanuric chloride  Meinir Jones, PhDa, Cynthia Graham, PhDb,"— Presentation transcript:

1 Immunologic cross-reactivity between respiratory chemical sensitizers: Reactive dyes and cyanuric chloride  Meinir Jones, PhDa, Cynthia Graham, PhDb, Anthony Newman Taylor, FRCP, FFOMa, Katherine Sarlo, PhDc, Viviene Hoyle, PhDd, Meryl H. Karol, PhDb  Journal of Allergy and Clinical Immunology  Volume 102, Issue 5, Pages (November 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Structures of CyCl, PrOr, and Rem B.
Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 RAST and RAST inhibition of serum C547. A, Serum from this PrOr-exposed worker demonstrated 10.6% RAST binding to PrOr-HSA–coated disks that was inhibited by PrOr-HSA (1.6% binding), but not by CyCl-HSA (10.0% binding). B, Serum demonstrated 1.8% RAST binding to CyCl-HSA disks. Binding was inhibited equally by PrOr-HSA (0.7% binding) and by CyCl-HSA (0.9% binding). Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Prediction of allergenic features of PrOr by using Structure Activity Relationship model. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions


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