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Osteoarthritis and Cartilage

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Presentation on theme: "Osteoarthritis and Cartilage"— Presentation transcript:

1 Osteoarthritis and Cartilage
Chondrocyte death and mitochondrial dysfunction are mediated by cartilage friction and shear strain  E.D. Bonnevie, M.L. Delco, N. Jasty, L. Bartell, L.A. Fortier, I. Cohen, L.J. Bonassar  Osteoarthritis and Cartilage  Volume 24, (April 2016) DOI: /j.joca Copyright © Terms and Conditions

2 Figure 1 (A) Friction coefficient vs sliding speed (n = 4). (B) Local shear strains were tracked on a confocal microscope. (C) Local shear strains were high in PBS lubricated tissue compared to control. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Figure 2 (A-C) Live/dead staining. (D) Percent cell death vs tissue depth. (E-G) MT (green) and active MT (red) staining. (D) Percent MT dysfunction vs tissue depth (n = 4). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions


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