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Taia T. Wang, Jeffrey V. Ravetch  Immunity 

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1 Immune Complexes: Not Just an Innocent Bystander in Chronic Viral Infection 
Taia T. Wang, Jeffrey V. Ravetch  Immunity  Volume 42, Issue 2, Pages (February 2015) DOI: /j.immuni Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Crosslinking of Activating FcγRs Is Required for IgG Effector Functions Such as ADCC (Left) Model for B cell depletion through administration of an anti-CD20 mAb. Fc domains of anti-CD20 IgG bound to B cells crosslink activating FcγRs on the effector cell, resulting in cytotoxicity. (Right) Model for blocking of FcγRs in chronic LCMV infection. IC formed in LCMV could block activating FcγRs, while not causing substantial receptor crosslinking, thus blocking IgG-mediated effector functions such as ADCC. Immunity  , DOI: ( /j.immuni ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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