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Volume 19, Issue 1, Pages (February 2012)

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Presentation on theme: "Volume 19, Issue 1, Pages (February 2012)"— Presentation transcript:

1 Volume 19, Issue 1, Pages 65-67 (February 2012)
Are polycyclic aromatic hydrocarbons from fossil emissions potential hormone-analogue sources for modern man?  Sergio Manzetti  Pathophysiology  Volume 19, Issue 1, Pages (February 2012) DOI: /j.pathophys Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 The resemblance between benzo[a]pyrene and hormones. Top left, A: benzo[a]pyrene; B: benzo[a]pyrene diol epoxide; C: estrogen; D: testosterone. Note how the hormones bear hydrophilic groups on the angular benzene ring, which are similarly produced in the metabolism of benzo[a]pyrene. Pathophysiology  , 65-67DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Chart 1 A simple illustration of a correlation between estrogen-like geometry and relative mutagenicity of PAHs. Y-axis: Logaritmic scale of the TA100 relative mutagenicityies of 12 PAH based on their derivating epoxide forms [5–7]; X-axis: Logarithmic scale of estrogen-like geometry [8]. From left to right: 1: Triphenylene; 2: Phenanthrene; 3: Benzo[e]pyrene; 4: Benzo[c]phenanthrene; 5: Dibenzo[a,l]pyrene 6: Benzoanthracene; 7: Benzo[g]chrysene; 8: Dibenzo[a,h]pyrene; 9: Benzo[c]chrysene; 10: Chrysene; 11: Benzo[a]pyrene; 12: Anthanthrene. Pathophysiology  , 65-67DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions


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