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Volume 70, Issue 7, Pages (October 2006)

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1 Volume 70, Issue 7, Pages 1207-1213 (October 2006)
Essential roles of CFEX-mediated Cl−–oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis  P.S. Aronson  Kidney International  Volume 70, Issue 7, Pages (October 2006) DOI: /sj.ki Copyright © 2006 International Society of Nephrology Terms and Conditions

2 Figure 1 Models of apical membrane NaCl entry mediated by different modes of Cl−–base exchange. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

3 Figure 2 Proximal tubule transport defects in CFEX-null mice. (a) Cl−–oxalate exchange, (b) oxalate–sulfate exchange, and (c) Cl−–formate exchange assayed in renal brush border vesicles from wild-type and CFEX-null mice.36 (d) Effects of formate and oxalate on volume absorption (Jv) by proximal tubules microperfused in situ in wild-type and CFEX-null mice.40 Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

4 Figure 3 Calcium oxalate urolithiasis owing to abnormal oxalate homeostasis in CFEX-null mice.36 (a) Stones found in the bladder of a CFEX-null mouse. (b) Calcium oxalate mass in the urinary space of a CFEX-null mouse. Oxalate concentrations in (c) urine, (d) plasma, and (e) feces in wild-type and CFEX-null mice fed a control oxalate-containing diet or an oxalate-free diet. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

5 Figure 4 Oxalate homeostasis in normal and CFEX-knockout mice. The primary defect in CFEX-null mice is a greatly decreased secretory flux of oxalate in the intestine, leading to enhanced net absorption of ingested oxalate, increased plasma oxalate concentration, and increased renal oxalate excretion. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions


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