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Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall  Monsur Kazi, MD, Johan Thyberg, MD, PhD,

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Presentation on theme: "Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall  Monsur Kazi, MD, Johan Thyberg, MD, PhD,"— Presentation transcript:

1 Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall  Monsur Kazi, MD, Johan Thyberg, MD, PhD, Piotr Religa, MD, PhD, Joy Roy, MD, PhD, Per Eriksson, PhD, Ulf Hedin, MD, PhD, Jesper Swedenborg, MD, PhD  Journal of Vascular Surgery  Volume 38, Issue 6, Pages (December 2003) DOI: /S (03)

2 Fig 1 Photomicrographs of AAA wall not covered with thrombus (NT; A, C, E, G) and in AAA wall covered with thrombus (T; B, D, F, H). A, Adventitia; M, media; I, intima; arrows, elastin (C), SMC (E), and CD3-positive cells (H); bars, 100 μm. Journal of Vascular Surgery  , DOI: ( /S (03) )

3 Fig 2 Quantitative analysis (A, B, D, K) and semiquantitative analysis (C, E-J) of AAA sections from aneurysm wall without thrombus (circles) and aneurysm wall covered with thrombus (triangles). *Statistically significant difference between groups at P < .05. Journal of Vascular Surgery  , DOI: ( /S (03) )

4 Fig 3 Photomicrographs show inflammatory cells in AAA wall not covered with thrombus (NT; A, C, E, G) and AAA wall covered with thrombus (T; B, D, F, H). Macrophages were detected with an antibody against CD68 (A, B), B cells with CD20 (C, D), T helper cells with CD4 (E, F), and cytotoxic T cells with CD 8 (G, H). M, Media; I, intima; arrows, macrophages, CD20, CD4, and CD8-positive cells; bars, 100 μm. Journal of Vascular Surgery  , DOI: ( /S (03) )

5 Fig 4 TUNEL staining demonstrates presence of apoptotic cells in AAA wall not covered with thrombus (NT) and in AAA wall covered with thrombus (T). Bars, 100 μm. Journal of Vascular Surgery  , DOI: ( /S (03) )

6 Fig 5 Electron micrographs of medial (A-C) and adventitial (D-F) tissue in aneurysm wall without thrombus. A, Differentiated, myofilament-rich smooth muscle cells. B, C, Dedifferentiated, endoplasmic reticulum–rich and Golgi apparatus–rich smooth muscle cells. D, Macrophage rich in lysosomes with phagocytized material. E, Activated B cell with extensive endoplasmic reticulum. F, Lymphocyte in close contact with a dying or disintegrating cell. BC, B-cell; C, collagen fibrils; E, elastin; ER, endoplasmic reticulum; DC, dying cell; F, myofilaments; G, stacks of Golgi cisternae; Ly, lymphocyte; MP, macrophage; N, nucleus; bars, 1 μm. Journal of Vascular Surgery  , DOI: ( /S (03) )

7 Fig 6 Electron micrographs of aneurysm wall covered with thrombus. A, Endoplasmic reticulum–rich and Golgi apparatus–rich smooth muscle cell. B, Myofilament-rich smooth muscle cell in the media. C, Apoptotic and necrotic cells in the adventitia. D, Oddly shaped cells with long processes, probably indicating ongoing migration. C, Collagen; DC, dying cells; ER, endoplasmic reticulum; F, myofilaments; N, nucleus; bars, 1 μm. Journal of Vascular Surgery  , DOI: ( /S (03) )

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