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Percentages of reactions showing different fluxes at doubled HCO3 levels per group as identified by the solution space sampling of the genome-scale metabolic model of P. tricornutum. Percentages of reactions showing different fluxes at doubled HCO3 levels per group as identified by the solution space sampling of the genome-scale metabolic model of P. tricornutum. Pigment metabolism contains most of the reactions with different fluxes under the two conditions, i.e., 43% of the reactions in this group were upregulated at high HCO3 concentrations, followed by nucleotide metabolism (19% in total; 17% upregulated and 2% downregulated) and amino acid metabolism (10%). Three reactions, namely, ITCY_c, CMP_c, and ITPA_c, belonging to nucleotide metabolism were downregulated at high HCO3 concentrations. Jennifer Levering et al. mSystems 2017; doi: /mSystems
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