1. Herman Suit Lecture CTOS 2013 New York, NY
Kevan Shokat, PhD
Herman Suit Lecture
CTOS 2013
New York, NY

2. Herman Suit, MD, DPhil, FASTRO
Organizational meeting 1993
CTOS 1st meeting 1995
CTOS incorporated 1997
2010

3. Kevan Shokat, PhD
Professor and Chair, Department of Cellular and Molecular Pharmacology, UCSF
Professor of Chemistry, UC Berkeley
HHMI Scientist, 2005-
National Academy of Sciences, 2010
BA Chemistry, Reed College, 1986
PhD Chemistry, UC Berkeley, 1991 (P. G. Shultz)
Postdoc-C.C. Goodnow
Princeton
UC Berkeley and UCSF (Professor: 2001)

4. PhD years
Nature 1989; 338: 269

5. By exploiting the highly conserved nature of the ATP binding site across the kinase superfamily and the availability of structural information from other protein kinases, we were able to engineer novel substrate specificity for v-Src without any detailed structural information about v-Src itself.
That we used an unrelated kinase as a blueprint for designing orthogonal ATP analogs to tag the direct cellular substrates of v-Src suggests that this approach should work for other kinases as well. If it does, then it might be possible to systematically begin to dissect the complex proximal signaling cascades controlled by cellular tyrosine kinases.