1. Volume 88, Issue 4, Pages 660-662 (October 2015)
Klotho upregulation by rapamycin protects against vascular disease in CKD 
Takayuki Hamano 
Kidney International 
Volume 88, Issue 4, Pages (October 2015)
DOI: /ki
Copyright © 2015 International Society of Nephrology Terms and Conditions

2. Figure 1
The effect of mTOR inhibition on two types of vasculopathy often seen in patients with chronic kidney disease. mTOR inhibitors, such as rapamycin and everolimus, stabilize atherosclerotic plaque and/or regress atherosclerosis by inhibiting VSMC proliferation, promoting protective autophagy, and attenuating nuclear factor-κB (NF-κB) activation. The protective effect of mTOR inhibitors on medial calcification was also reported. The main mechanisms include the upregulation of Klotho.
Kidney International  , DOI: ( /ki )
Copyright © 2015 International Society of Nephrology Terms and Conditions