1. Institute for Systems Biology & Bellevue School District
Static Network of the Great Salt Lake Ecosystem
This is the static network of the GSL. The students have discovered a relationship between salinity and halobacterium growth. We will now see how that relationship will be visualized in the network –please note they have data only for effect of salinity on Halobacterium growth and they do not have knowledge about other quantitative relationships –please be sure to distinguish hypothesis from fact.
Institute for Systems Biology & Bellevue School District

2. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
First they started with a salinity of 2.5M –what was the effect on growth of halo?
Institute for Systems Biology

3. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
Observation: Halo did not grow at all
Institute for Systems Biology

4. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
At a salinity of 3.0M –what was the effect on growth of halo?
Institute for Systems Biology

5. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
Observation: Halo showed moderate growth
Institute for Systems Biology

6. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
At a salinity of 3.5M –what was the effect on growth of halo?
Institute for Systems Biology

7. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
Observation: Halo grew even better
Institute for Systems Biology

8. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
At a salinity of 4.0M –what was the effect on growth of halo?
Institute for Systems Biology

9. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
Observation: Halo grew extremely well
Institute for Systems Biology

10. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
At a salinity of 4.5M –what was the effect on growth of halo?
Institute for Systems Biology

11. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
Observation: Halo growth was less relative to growth at 4.0M; 4.5M is approximately the salinity of the North arm of the lake.
Make students HYPOTHESIZE what will happen to rest of the network –say starting with other nodes directly affected by salinity. Students should first identify the appropriate nodes.
Institute for Systems Biology

12. Institute for Systems Biology

13. Institute for Systems Biology
Effect of salinity on Halobacterium growth:
Visualization Based on Experimental Data
Observation: Halo growth was less relative to growth at 4.0M; 4.5M is approximately the salinity of the North arm of the lake.
Make students HYPOTHESIZE what will happen to rest of the network –say starting with other nodes directly affected by salinity. Students should first identify the appropriate nodes.
Institute for Systems Biology

14. Formulate new hypotheses:
What is the effect of salinity on other species in this network
Observation: Halo growth was less relative to growth at 4.0M; 4.5M is approximately the salinity of the North arm of the lake.
Institute for Systems Biology

15. Formulate new hypotheses:
What is the effect of salinity on other species in this network
Observation: Halo growth was less relative to growth at 4.0M; 4.5M is approximately the salinity of the North arm of the lake.
Institute for Systems Biology

16. Formulate new hypotheses:
What is the effect of salinity on other species in this network
Observation: Halo growth was less relative to growth at 4.0M; 4.5M is approximately the salinity of the North arm of the lake.
Institute for Systems Biology

17. Institute for Systems Biology

18. Institute for Systems Biology
North arm
South arm
Observation: Halo growth was less relative to growth at 4.0M; 4.5M is approximately the salinity of the North arm of the lake.
Institute for Systems Biology