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Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4  Katrina A.B. Goddard, John S. Witte, Brian K.

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Presentation on theme: "Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4  Katrina A.B. Goddard, John S. Witte, Brian K."— Presentation transcript:

1 Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4  Katrina A.B. Goddard, John S. Witte, Brian K. Suarez, William J. Catalona, Jane M. Olson  The American Journal of Human Genetics  Volume 68, Issue 5, Pages (May 2001) DOI: /320103 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

2 Figure 1 LOD scores for a genome scan of sibships with CaP. Marker locations are indicated by tick marks above the lower axis. Five models are included: the baseline one-parameter model (black) and four models with one covariate each, including Gleason score (blue), age at onset (red), male-to-male transmission (green), and number of affected relatives (yellow). Horizontal lines correspond to LOD score cutpoints at α = .001 for baseline LOD score (cutpoint 2.07) and models including a single covariate (cutpoint 2.78). The American Journal of Human Genetics  , DOI: ( /320103) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

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