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Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection  Ravi Kumar, Sanjay Chhibber, Kusum Harjai  Kidney.

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Presentation on theme: "Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection  Ravi Kumar, Sanjay Chhibber, Kusum Harjai  Kidney."— Presentation transcript:

1 Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection  Ravi Kumar, Sanjay Chhibber, Kusum Harjai  Kidney International  Volume 76, Issue 3, Pages (August 2009) DOI: /ki Copyright © 2009 International Society of Nephrology Terms and Conditions

2 Figure 1 Renal bacterial load of infected mice killed on post-infection days 1, 3, and 5 after intraurethral challenge with Pseudomonas aeruginosa standard strain PA01 and its isogenic mutant strains. Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

3 Figure 2 Bladder bacterial load of mice killed on post-infection days 1, 3, and 5 after intraurethral challenge with Pseudomonas aeruginosa standard strain PA01 and its isogenic mutant strains. Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

4 Figure 3 Photomicrograph showing severe inflammation in the interstitium along with destruction of tubules and infiltration of neutrophils in the renal tissue of mice infected with standard strain PAO1 (H&E × 40). Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

5 Figure 4 Photomicrograph showing mild inflammation in the interstitium of mice infected with mutant strain JP1 (H&E × 40). Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

6 Figure 5 Photomicrograph showing marked inflammation with neutrophils in and on the bladder mucosal epithelium along with shedding of cells and vascular permeability in mice infected with standard strain PAO1 (H&E × 40). Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

7 Figure 6 Photomicrograph showing no significant changes in the bladder tissue of mice infected with mutant strain JP1 (H&E × 40). Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions


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