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EGFL7 promoted density and maturation state of glioma vessels

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Presentation on theme: "EGFL7 promoted density and maturation state of glioma vessels"— Presentation transcript:

1 EGFL7 promoted density and maturation state of glioma vessels
EGFL7 promoted density and maturation state of glioma vessels A, BCD31 staining for endothelial cells revealed increased tumor vascularization in mice bearing human EGFL7 (hE7)‐ or murine EGFL7 (mE7)‐positive tumors (n = 3; one‐way ANOVA).C, DT2‐weighted magnetic resonance imaging (MRI) analysis of these brains confirmed that all mice developed tumors of similar size. T1‐weighted MRI images showed decreased vessel permeability as measured by Gadovist extravasation in tumors expressing hE7 or mE7 (red arrows; n = 6; one‐way ANOVA).E–JEnhanced maturation of glioma vessels in the presence of hE7 or mE7 was verified by increased co‐localization of (E, F) PDGFRβ (pericytes), (G, H) SMA (smooth muscle cells), or (I, J) Col IV (basement membrane) with CD31 (n = 3; one‐way ANOVA; quantifications normalized to CD31).Data information: Data presented as mean ± SEM; AU, arbitrary units. Scale bars represent 60 μm (A, E, G and I) or 2.5 mm (C). Nevenka Dudvarski Stanković et al. EMBO Mol Med. 2018;10:e8420 © as stated in the article, figure or figure legend

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