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Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC  Mi Jeong Hong, MS, Yi Young Choi, MS, Ji-Ae Jang, MS, Hye-Jin.

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Presentation on theme: "Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC  Mi Jeong Hong, MS, Yi Young Choi, MS, Ji-Ae Jang, MS, Hye-Jin."— Presentation transcript:

1 Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC 
Mi Jeong Hong, MS, Yi Young Choi, MS, Ji-Ae Jang, MS, Hye-Jin Jung, MS, Shin Yup Lee, MD, PhD, Won Kee Lee, PhD, Seung Soo Yoo, MD, Jaehee Lee, MD, Seung Ick Cha, MD, PhD, Chang Ho Kim, MD, PhD, Eungbae Lee, MD, PhD, Hyo-Sung Jeon, PhD, Ji Woong Son, MD, Jae Yong Park, MD, PhD  Journal of Thoracic Oncology  Volume 8, Issue 6, Pages (June 2013) DOI: /JTO.0b013e318288dc0a Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Overall survival and disease-free survival curves according to genotypes: (A) pre-miR-149 rs TC or CC vs. TT genotype; (B) pre-miR-196a rs CT or TT vs. CC genotype, and (C) the combined genotypes of the two polymorphisms (1 and 2 good genotypes vs. none of good genotypes). p values in the multivariate Cox hazard models. Journal of Thoracic Oncology 2013 8, DOI: ( /JTO.0b013e318288dc0a) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Effect of the rs T>C genotypes on miR-149 expression. Glyceraldehyde 3-phosphate dehydrogenase and the small nuclear RNA U6 were used to normalize the expression of primary and mature miR-149, respectively. (A) Expression levels of primary and mature miR-149 in tumors and normal lung tissues. Expression levels of primary and mature forms of miR-149 by the rs T>C genotypes in normal lung tissues (B) and tumor tissues (C). Data represent median and quartiles. *p = 0.02, **p = 0.01. Journal of Thoracic Oncology 2013 8, DOI: ( /JTO.0b013e318288dc0a) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

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