1. Taking the Broad View on B Cell Affinity Maturation
Karlynn E. Neu, Patrick C. Wilson 
Immunity 
Volume 44, Issue 3, Pages (March 2016)
DOI: /j.immuni
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
The Functional B Cell Repertoire Is Formed Largely by Affinity Maturation
The findings of Kuraoka et al. (2016) suggest that a wider range of B cell affinities are accepted for entry into germinal centers (GCs) than was previously thought, resulting in increased initial heterogeneity. After entry, the early GC response is mostly comprised of B cell clones whose BCR gene usage has an innate affinity for the antigen. As the immune response progresses, antigen becomes more limited, increasing competition. Instead of lower-affinity B cells being eradicated, as previously expected, some survive and undergo extensive affinity maturation to achieve a competitive edge and contribute to the diversity of the late GC response.
Immunity  , DOI: ( /j.immuni )
Copyright © 2016 Elsevier Inc. Terms and Conditions