1. CEVA SANTE ANIMALE
GUMBORO DISEASE

2. 1987 : Belgium, The Netherlands
EPIDEMIOLOGY
Form 1990 à 2000 : Big expension
1988 : France, UK, Germany,
Jordan, Saudi Arabia,
Egypt
1987 : Belgium, The Netherlands
1965 : USA
1989 : Greece, Portugal, Israel,
India, South of Africa
 1970 : West of Africa
1990 : Thaïland
1998 : Latine America

3. Clinical Signs Thigh linear haemorrhage
Swollen, oedematous bursa of Fabricius
Haemorragic bursa of Fabricius

4. Gumboro impact on Chicks
Up to 2 or 3 weeks
IMMUNODEPRESSION MORTALITY without mortality without
Immunodepression
The IMPACT will depend
on the age of the chicks

5. Gumboro pressure at the farms Day old chick immunized through
14-24 Days old Chick
1 Day old Chick
Vaccine virus
7-10 Days old Chick
Field Virus
Field Virus
Day old chick are sensible to the Virus (Competition against the field and the vaccine)
Day old chick immunized through
Maternal Antibodies

6. Importance of the vaccination
Date

7. Importance of the vaccination
Date
Antibody rate
Passive Immunity
Active Immunity
OWN ANTIBODIES
VACCINATION
MATERNAL ANTIBODIES
Protected chicks
Vaccine intake
Protection level
limit
Unprotected
Chicks
Day 1
???
Age

8. Chicks Heterogeneity MDA
Antibody rate
Passive Immunity
Active Immunity
OWN ANTIBODIES
OWN ANTIBODIES
OWN ANTIBODIES
OWN ANTIBODIES
VACCINATION
MATERNAL ANTIBODIES
Protected chicks
Vaccine intake
Protection level
limit
Unprotected
Chicks J1
???
???
???
Age

9. It is a COMPETITION and only the best will succeed
Field versus vaccine
It is a COMPETITION and only the best will succeed
The best is the one who is able to overcome good amount of maternally derived antibodies:
the first to penetrate
The best is the one who is able to quickly replicate :
he will keep his advance
The best is the more abondant :
field virus : to be decreased by disinfection
Vaccine virus : to be increased by the vaccine quality and the quality of its administration

10. CEVA Vaccines against GUMBORO
Subclinical infection, with economical losses:
Cevac® GUMBO L, Intermediate vaccine, strong protection and seroconversion
Very virulent Gumboro, with acute mortality:
Cevac® IBD L, classical virus with fast replication (intermediate + vaccine), the only able to give high and early protection against vv IBDV )

11. CEVA vaccination programs

12. CEVA vaccination programs

13. GUMBORO HISTORY 1965 reached the commercial eggs production
No vv IBD in USA
Emerged for the first time in USA in 1957
1965 reached the commercial eggs production
1976 mortality was controlled through vaccination