1. Optimal Experimental Design
Optimal Times to get Serum Samples:
D - optimal experimental Design
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10. An Example: Monitoring Lidocaine Optimally
Loading infusion over 1 min, then mg/min. 10 subjects.
Conventional monitoring strategy – 8 measurements, at 5, 10, 30, 60, 120, 180, 360, and 720 min into the regimen.
V=30L, Kel=.0242hr-1, Kcp=.066hr-1, and Kpc=.038hr-1.
Assay SD = x conc.
D – Optimal strategy – 4 samples, each in duplicate, at 1, 10, 70, and 720 min.
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14. Bottom line for research or for TDM
Don’t wait for steady state
Don’t wait for distribution after the dose
Start TDM with 1st dose
Use D-opt principles
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