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Volume 139, Issue 4, Pages e5 (October 2010)

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Presentation on theme: "Volume 139, Issue 4, Pages e5 (October 2010)"— Presentation transcript:

1 Volume 139, Issue 4, Pages 1218-1229.e5 (October 2010)
Tenofovir and Entecavir Are the Most Effective Antiviral Agents for Chronic Hepatitis B: A Systematic Review and Bayesian Meta-analyses  Gloria Woo, George Tomlinson, Yasunori Nishikawa, Matthew Kowgier, Morris Sherman, David K.H. Wong, Ba Pham, Wendy J. Ungar, Thomas R. Einarson, E. Jenny Heathcote, Murray Krahn  Gastroenterology  Volume 139, Issue 4, Pages e5 (October 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Bayesian MTC method. Binary efficacy data of pair-wise comparisons are entered into a Bayesian MTC model that calculates indirect treatment effects and the probability of a response from the common comparator treatment (PB). The indirect treatment effects (OR of A vs C) and probability of response of the common comparator (PB) are used to calculate the probability of response for each of the treatments (PA and PC). T1, trial 1; T2, trial 2; xA, number of responders on treatment A; nA, number of patients on treatment A; xB, number of responders on treatment B; nB, number of patients on treatment B; xC, number of responders on treatment C; nC, number of patients on treatment C; PA, probability of a response from treatment A; PB, probability of response from treatment B; Rx, treatment effect. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Study selection and disposition.
Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Cochrane risk of bias tool results.
Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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