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Somatic Mutations of the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor and Tyrosine Kinase Inhibitor Response to TKIs in Non-small Cell Lung.

Published byΤερψιχόρη Παπαγεωργίου Modified over 5 years ago

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Presentation on theme: "Somatic Mutations of the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor and Tyrosine Kinase Inhibitor Response to TKIs in Non-small Cell Lung."— Presentation transcript:

1 Somatic Mutations of the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor and Tyrosine Kinase Inhibitor Response to TKIs in Non-small Cell Lung Cancer: An Analytical Database  Samuel Murray, PhD, Issa J. Dahabreh, Helena Linardou, MD, PhD, Menelaos Manoloukos, MSc, Dimitrios Bafaloukos, MD, Paris Kosmidis, MD  Journal of Thoracic Oncology  Volume 3, Issue 8, Pages (August 2008) DOI: /JTO.0b013e f3 Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Trial flow of database generation and data extraction.
Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e f3) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Distribution of somatic EGFR mutations. A, per exon and B, according to type (entire population). Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e f3) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Frequency of reported incidence of somatic mutations in EGFR. Incidence of somatic mutations that have been reported on 1, 2, 3, 4, and ≥5 separate occasions. Also the number (incidence) of mutations that have a cumulative frequency of ≥1% of the total number of mutations reported (n = 3305). Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e f3) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Response rates for somatic mutations per exon, total population, and per mutational type (cumulative data of treated patients for which response data exists). Responses are characterized as CR + PR, stable disease (disease stabilization), PD, nonevaluable. Total represents the percentage of each response group per stratification out of 100%. Point mutations represent missense mutations and frameshift mutations, Dels-Ins are a combination of deletions, insertions, and deletional-insertions (according to Table 2). All = all mutations. Journal of Thoracic Oncology 2008 3, DOI: ( /JTO.0b013e f3) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

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