1. Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function 
Julia Seyfarth, Sutharsan Sivagurunathan, Sarah Ricken, Gerhard Weinreich, Laura Olbrich, Christian Taube, Ertan Mayatepek, Dirk Schramm, Marc Jacobsen 
Journal of Cystic Fibrosis 
Volume 18, Issue 1, Pages (January 2019)
DOI: /j.jcf
Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions

2. Fig. 1
IL-7 serum levels in patients with cystic fibrosis (CF) and healthy controls. (A, B) IL-7 serum levels of patients with CF (n = 164) and healthy controls (n = 60) as well as for age-matched subgroups of CF patients (CFadult: n = 130; CFyouth: n = 34 and controls (B). Median values are indicated. Nominal p-values for the Mann-Whitney U test (two-tailed) are given.
Journal of Cystic Fibrosis  , 71-77DOI: ( /j.jcf )
Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions

3. Fig. 2
Effects of clinical features and infections of CF patients on IL-7 serum concentrations. (A) IL-7 serum levels for CF patients with or without Pseudomonas (P.) aeruginosa, Aspergillus (A.) fumigatus, or Staphylococcus (S.) aureus infection. IL-7 serum levels in patients chronically infected with P. aeruginosa (left graph; negative: n = 95, positive: n = 69), A. fumigatus (middle graph; negative: n = 126, positive: n = 38), and S. aureus (right graph; negative: n = 99, positive: n = 65) are shown. Median values for groups and nominal p-values for the Mann-Whitney U test (two-tailed) are indicated. (B) CF patients BMI (left graph, n = 154) and FEV1%pred (right graph, n = 155) were correlated with serum IL-7. Spearman's rank correlation coefficient r and the respective p-values are indicated. A trend line was fitted by linear regression analysis. (C) IL-7 serum levels are shown for CF patient subgroups classified according to pancreatic insufficiency (left graph, no: n = 142; yes: n = 22) and diabetes (right graph, no: n = 87; yes: n = 77). Median values for groups and nominal p-values for the Mann-Whitney U test (two-tailed) are indicated.
Journal of Cystic Fibrosis  , 71-77DOI: ( /j.jcf )
Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions

4. Fig. 3
Time course analyses of IL-7 serum concentrations and clinical features for a subgroup of CF patients (n = 78). (A) CF patients FEV1%pred (left graph) and BMI (right graph) are shown for both time points (B). IL-7 serum concentrations are shown for both time points. CF patients shown for time point (TP)2 were recruited 1 year +/- 6 months after TP1. (A, B) Median values for groups and nominal p-values for the Mann-Whitney U test (two-tailed) are indicated. (C) CF patients FEV1%pred (left graph) and BMI (right graph) are correlated with IL-7 serum concentration at the second time point. Spearman's rank correlation coefficient r and the respective p-values are indicated. A trend line was fitted by linear regression analysis.
Journal of Cystic Fibrosis  , 71-77DOI: ( /j.jcf )
Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions