1. Mapping Tumor-Suppressor Genes with Multipoint Statistics from Copy-Number– Variation Data 
Iuliana Ionita, Raoul-Sam Daruwala, Bud Mishra 
The American Journal of Human Genetics 
Volume 79, Issue 1, Pages (July 2006)
DOI: /504354
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

2. Figure 1
Prior score as a function of the length of the interval. A priori, shorter intervals receive higher weight than larger intervals.
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

3. Figure 2
The tail probability P(Sw⩾k) for different numbers of breakpoints k (0≤k≤20) and different window sizes w. Sw is the maximum number of breakpoints in a window of length w. The total number of breakpoints in the region is N=50.
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

4. Figure 3
Depiction of the simulation process described in the text. A single precancerous cell (both copies of the TSG are nonfunctional) starts multiplying indefinitely. Over time, the new progenitor cells also incur other independent damage (i.e., deletions). The tumor sample that we collected comprised different tumor cells and some normal cells.
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

5. Figure 4
Box plots of the Jaccard measure of overlap for each of the six models (table 1). Fifty data sets are simulated according to each model, and the distribution of the resulting 50 overlap measures is depicted in each box plot. Average intermarker distance is 10 kb. A, LR. B, Max.
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

6. Figure 5
Box plots of the sensitivity measure for each of the six models (table 1). Fifty data sets are simulated according to each model, and the distribution of the resulting 50 sensitivity measures is depicted in each box plot. Average intermarker distance is 10 kb. A, LR. B, Max.
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

7. Figure 6
Box plots of the Jaccard measure of overlap for each of the six models (table 1). Fifty data sets are simulated according to each model, and the distribution of the resulting 50 overlap measures is depicted in each box plot. Average intermarker distance is 20 kb. A, LR. B, Max.
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

8. Figure 7
Box plots of the sensitivity measure for each of the six models (table 1). Fifty data sets are simulated according to each model, and the distribution of the resulting 50 sensitivity measures is depicted in each box plot. Average intermarker distance is 20 kb. A, LR. B, Max.
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

9. Figure 8
The histogram for the log2 ratio values for all SNPs in all 70 tumors, together with an empirical null density fitted to the histogram: N(μˆ,σˆ2).
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

10. Figure 9
Copy-number histogram for individual samples (samples 1–16). Overlaid is the fitted empirical null density N(μˆ0,σˆ02).
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

11. Figure 10
Copy-number histogram for individual samples (samples 17–32). Overlaid is the fitted empirical null density N(μˆ0,σˆ02).
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

12. Figure 11
Copy-number histogram for individual samples (samples 33–48). Overlaid is the fitted empirical null density N(μˆ0,σˆ02).
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

13. Figure 12
Copy-number histogram for individual samples (samples 49–64). Overlaid is the fitted empirical null density N(μˆ0,σˆ02).
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

14. Figure 13
Copy-number histogram for individual samples (samples 65–70). Overlaid is the fitted empirical null density N(μˆ0,σˆ02).
The American Journal of Human Genetics  , 13-22DOI: ( /504354)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions