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Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients  Pooja Khandelwal, Sabine Mellor-Heineke, Najibah.

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Presentation on theme: "Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients  Pooja Khandelwal, Sabine Mellor-Heineke, Najibah."— Presentation transcript:

1 Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients 
Pooja Khandelwal, Sabine Mellor-Heineke, Najibah Rehman, Adam Lane, Kristi Smiley, Joyce Villanueva, Rebecca A. Marsh, Michael S. Grimley, Stella M. Davies, Alexandra H. Filipovich  Biology of Blood and Marrow Transplantation  Volume 22, Issue 4, Pages (April 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Distribution of grades I to IV acute GVHD in the study group.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Median cytokine value in pg/mL in patients with isolated engraftment syndrome (ES), isolated acute GVHD, both ES and GVHD, and neither ES nor acute GVHD (No ES or GVHD). Median onset of engraftment syndrome and acute GVHD is depicted by arrows. Cytokines include (A) IL-1β, (B) IL-6, (C) IL-12, (D) IL-13, and (E) IL-4. See Figure 3 for time points that were of statistical significance between isolated ES, isolated GVHD, and neither ES nor acute GVHD. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Box and whiskers plots of plasma cytokines at statistically significant time points. (A) IL-1β, (B) IL-6, (C) IL-12, (D) IL-13, and (E) IL-4. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Median cytokine value in pg/mL in patients with isolated engraftment syndrome (ES), isolated acute GVHD, both ES and GVHD, and neither ES nor acute GVHD (No ES or GVHD) until 12 weeks after allogeneic SCT. Arrows depict median time at onset of ES and GVHD. Cytokines include (A) MCP-1 and (B) IL-8. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions


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