1. Proteins Kinases: Chromatin-Associated Enzymes?
Chi-Wing Chow, Roger J. Davis 
Cell 
Volume 127, Issue 5, Pages (December 2006)
DOI: /j.cell
Copyright © 2006 Elsevier Inc. Terms and Conditions

2. Figure 1
Regulation of Gene Transcription by Protein Kinases Tethered to Chromatin
Extracellular stimuli may activate signaling pathways that lead to the recruitment of protein kinases to target genes. The recruitment may be mediated by sequence-specific DNA-binding proteins (such as transcription factors). However, protein kinases may also be recruited to the entire transcribed region of the target genes. One possible mechanism for this is a direct association between the protein kinase and the RNA Pol II transcription elongation complex. In some instances, the 3′ noncoding region is critical for the recruitment of protein kinases to the transcribed region of the gene. The tethered protein kinases may regulate the phosphorylation of transcription factors, histones, and chromatin remodeling enzymes. Functions of tethered protein kinases may include initiation, elongation, termination, and other processes influenced by RNA Pol II.
Cell  , DOI: ( /j.cell )
Copyright © 2006 Elsevier Inc. Terms and Conditions