1. Chemotherapeutic Drug Combination Index Description
Drug Combination Study Summary (SU-DHL-8)
Chemotherapeutic Drug
CI (IC90)
CI (IC75)
CI (IC50)
Combination Index Description
Bleomycin
0.59 ± 0.04
0.53 ± 0.05
0.48 ± 0.06
Synergy
Carboplatin
0.41 ± 0.11
0.47 ± 0.11
0.57 ± 0.11
Chlorambucil
0.73 ± 0.07
0.69 ± 0.07
0.65 ± 0.07
Moderate Synergy
Doxorubicin
0.85 ± 0.05
0.76 ± 0.04
0.68 ± 0.04
Etoposide
0.79 ± 0.07
0.76 ± 0.10
0.75 ± 0.14 b
Dacetuzumab upregulates Bid (Ramos)
Bid
22 kDa C D
0.33 2 4 6 8 24 32 48 56
Hours
Supplementary Figure 3 Lewis, et al.