1. Volume 42, Issue 6, Pages 907-913 (June 2005)
Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice 
Sang K. Kim, Young C. Kim 
Journal of Hepatology 
Volume 42, Issue 6, Pages (June 2005)
DOI: /j.jhep
Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

2. Fig. 1 Metabolic pathway of sulfur-containing amino acids.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

3. Fig. 2
Changes in hepatic levels of major sulfur amino acid metabolites in mice provided with betaine (1%) in drinking water. Each value is the mean±SEM for 5–7 mice. *, **, ***Significantly different from controls measured at the same time point (Student's t-test, P<0.05, 0.01, 0.001, respectively). Values with different letters (a, b, c) are significantly different one from another (one-way ANOVA followed by Newman–Keuls multiple range test, P<0.05). The concentration of methionine, SAM, SAH, cysteine, GSH and taurine measured at the initiation of betaine supplementation is 45±2, 99±3, 25±3, 121±5, 7600±300 and 14,500±600nmol/g liver, respectively.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

4. Fig. 3
Effect of dietary betaine on chloroform-induced hepatotoxicity in mice. Mice were challenged by chloroform (0.5ml/kg, ip) following betaine supplementation for 2 weeks. Animals were sacrificed 24h after chloroform treatment. Value given is the mean±SEM for seven mice. Values with different letters (a, b, c) are significantly different one from another (one-way ANOVA followed by Newman–Keuls multiple range test, P<0.05).
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2005 European Association for the Study of the Liver Terms and Conditions