1. The role of histone deacetylases in asthma and allergic diseases
Pankaj Bhavsar, PhD, Tehireem Ahmad, BSc, Ian M. Adcock, PhD 
Journal of Allergy and Clinical Immunology 
Volume 121, Issue 3, Pages (March 2008)
DOI: /j.jaci
Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
A, Allergen exposure or inflammatory stimuli lead to histone acetylation (histones shown protruding through pale blue DNA loops) by HATs and gene induction/cell activation. This process is reversed by specific HDACs, which mediate the actions of glucocorticoids. Nonhistone proteins are also targets for lysine acetylation and deacetylation by HATS and HDACs, with the effect on cell function depending on stimulus, readout, and cell type. B, Selective HDACs and sirtuins (SIRT) can target acetylated proteins' GR functions either directly or indirectly through Hsp90 or by blocking HAT/NF-κB interactions (see main text for details).
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions