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Cell Factory Engineering

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Presentation on theme: "Cell Factory Engineering"— Presentation transcript:

1 Cell Factory Engineering
Anne Mathilde Davy, Helene Faustrup Kildegaard, Mikael Rørdam Andersen  Cell Systems  Volume 4, Issue 3, Pages (March 2017) DOI: /j.cels Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Cell Systems 2017 4, 262-275DOI: (10.1016/j.cels.2017.02.010)
Copyright © 2017 Elsevier Inc. Terms and Conditions

3 Figure 1 Ontology of Different Types of Cellular Engineering Covered in This Review Cell Systems 2017 4, DOI: ( /j.cels ) Copyright © 2017 Elsevier Inc. Terms and Conditions

4 Figure 2 Engineering Strategies for Optimizing the Production of Native Metabolites Metabolites are denoted: S, substrate; S2, alternative substrate; X1-9, pathway intermediates; P, product of interest; BP, by-product. Generic engineering strategies are marked in blue and annotated as 1A–1I (described in the main text). Cell Systems 2017 4, DOI: ( /j.cels ) Copyright © 2017 Elsevier Inc. Terms and Conditions

5 Figure 3 Engineering Strategies for Heterologous Expression of Biosynthetic Pathways in a Eukaryotic Host Cell Metabolites are denoted: S, Substrate; X1-6, pathway intermediates; P, product of interest; CS, co-substrate; E1-10, enzymes; FG, functional group. The inserted heterologous pathway is marked in green. Generic engineering strategies are boxed in blue and annotated as 2A–2F (described in the main text). Cell Systems 2017 4, DOI: ( /j.cels ) Copyright © 2017 Elsevier Inc. Terms and Conditions

6 Figure 4 Overview of Generic Engineering Strategies for Expression of Proteins in a Eukaryotic Host Cell The inserted gene and its derived mRNA and polypeptide are marked in green. Generic engineering strategies are marked in blue and annotated as 3A–3J (described in the main text). Cell Systems 2017 4, DOI: ( /j.cels ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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