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Enhancing Trafficking of Adoptively Transferred Natural Killer Cells Via Prostaglandin E2 Signaling  Folashade Otegbeye, MBChB MPH, Stephen Moreton, Evelyn.

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1 Enhancing Trafficking of Adoptively Transferred Natural Killer Cells Via Prostaglandin E2 Signaling 
Folashade Otegbeye, MBChB MPH, Stephen Moreton, Evelyn Ojo, Nathan Mackowski, Amar Desai, PhD, Sanford Markowitz, MD PhD, David Wald, MD PhD  Biology of Blood and Marrow Transplantation  Volume 22, Issue 3, Pages S477-S478 (March 2016) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 Human NK cell proportion of total cells in mouse circulation 60h post-infusion of 10 × 106 CFSE-labeled NK cells (4 mice/group). NK = untreated NK cells; NAM-NK = NK cells expanded with nicotinamide 5mM; dmPGE-NK = NK cells incubated for 2h with dmPGE2 prior to infusion; SW* = 2mg/kg SW administered q12h pre-NK infusion for 6 doses. Biology of Blood and Marrow Transplantation  , S477-S478DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 Human NK cell proportion of total cells in crushed mouse spleen 60h post-infusion of 10 × 106 CFSE-labeled NK cells (4 mice/group). NK = untreated NK cells; NAM-NK = NK cells expanded with nicotinamide 5mM; dmPGE-NK = NK cells incubated for 2h with dmPGE2 prior to infusion; SW* = 2mg/kg SW administered q12h pre-NK infusion for 6 doses. Biology of Blood and Marrow Transplantation  , S477-S478DOI: ( /j.bbmt ) Copyright © Terms and Conditions

4 Figure 3 Human NK cell proportion of total cells in mouse bone marrow 60h post-infusion of 10 × 106 CFSE-labeled NK cells (4 mice/group). NK = untreated NK cells; NAM-NK = NK cells expanded with nicotinamide 5mM; dmPGE-NK = NK cells incubated for 2h with dmPGE2 prior to infusion; SW* = 2mg/kg SW administered q12h pre-NK infusion for 6 doses. Biology of Blood and Marrow Transplantation  , S477-S478DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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