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Torsades de pointes with pseudo–T wave alternans during rociletinib therapy: A novel manifestation of a rare side effect  Alexandra E. Teng, MD, Michael.

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Presentation on theme: "Torsades de pointes with pseudo–T wave alternans during rociletinib therapy: A novel manifestation of a rare side effect  Alexandra E. Teng, MD, Michael."— Presentation transcript:

1 Torsades de pointes with pseudo–T wave alternans during rociletinib therapy: A novel manifestation of a rare side effect  Alexandra E. Teng, MD, Michael Share, MD, Jeffrey J. Hsu, MD, Sarah R. Rettinger, MD, Edward Garon, MD, Jonathan Goldman, MD, Eric H. Yang, MD, Roderick Tung, MD, FHRS  HeartRhythm Case Reports  Volume 4, Issue 10, Pages (October 2018) DOI: /j.hrcr Copyright © 2018 Heart Rhythm Society Terms and Conditions

2 Figure 1 Twelve-lead electrocardiogram at presentation demonstrating macroscopic T-wave changes, with most pronounced abnormalities after premature atrial contraction–induced pauses. Corrected QT interval by the Bazett formula is 582 ms. Asterisks indicate premature atrial contractions and arrows indicate T-wave changes. HeartRhythm Case Reports 2018 4, DOI: ( /j.hrcr ) Copyright © 2018 Heart Rhythm Society Terms and Conditions

3 Figure 2 Premature ventricular contractions with R-on-T phenomenon during deeply inverted T-wave prolongation and initiation of torsades de pointes. HeartRhythm Case Reports 2018 4, DOI: ( /j.hrcr ) Copyright © 2018 Heart Rhythm Society Terms and Conditions

4 Figure 3 Gradual improvement in corrected QT interval prolongation and macroscopic T-wave changes on hospital days 2 through 5. HeartRhythm Case Reports 2018 4, DOI: ( /j.hrcr ) Copyright © 2018 Heart Rhythm Society Terms and Conditions

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