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Impact of Graft Cell Dose on Transplant Outcomes following Unrelated Donor Allogeneic Peripheral Blood Stem Cell Transplantation: Higher CD34+ Cell Doses.

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Presentation on theme: "Impact of Graft Cell Dose on Transplant Outcomes following Unrelated Donor Allogeneic Peripheral Blood Stem Cell Transplantation: Higher CD34+ Cell Doses."— Presentation transcript:

1 Impact of Graft Cell Dose on Transplant Outcomes following Unrelated Donor Allogeneic Peripheral Blood Stem Cell Transplantation: Higher CD34+ Cell Doses Are Associated with Decreased Relapse Rates  Ryotaro Nakamura, Nademanee Auayporn, David D. Smith, Joycelynne Palmer, Joel Y. Sun, Jeffrey Schriber, Vinod Pullarkat, Pablo Parker, Roberto Rodriguez, Anthony Stein, Joseph Rosenthal, Shirong Wang, Chatchada Karanas, Karl Gaal, David Senitzer, Stephen J. Forman  Biology of Blood and Marrow Transplantation  Volume 14, Issue 4, Pages (April 2008) DOI: /j.bbmt Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Neutrophil recovery is associated with CD34+ cell dose. There was a significant inverse relationship between higher CD34+ cell dose (log scale) and faster neutrophil engraftment (r = −0.16, P = .035). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Effect of CD34+ cell dose on relapse (a), DFS (b), and OS (c). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Absolute lymphocyte count on day +30 posttransplant is associated with CD34+ cell dose. There was a highly significant correlation between CD34+ cell dose infused and ALC on day 30 posttransplant (r = 0.378, P < .0001). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Effect of CD34+ cell dose on relapse in myeloid cancers (a) and lymphoid cancers (b). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions


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