1. Filling a GAP—An Optimized Probe for ER Ca2+ Imaging In Vivo
Roland Malli, Emrah Eroglu, Markus Waldeck-Weiermair, Wolfgang F. Graier 
Cell Chemical Biology 
Volume 23, Issue 6, Pages (June 2016)
DOI: /j.chembiol
Copyright © 2016 Elsevier Ltd Terms and Conditions

2. Figure 1
Putatively Distinct Sensing Mechanisms of Simple Genetically Encoded Fluorescent Probes
The probes consist of a sensor domain (gray/brown structure) and a FP (green barrel).
(A) Binding of the analyte (blue circle representing an ion or a small molecule) to the sensor domain induces a conformational distortion, which affects fluorescence of the adjacent FP. Red line indicates the transfer of the conformational change to the FP.
(B) The analyte binds in a close position to the FP barrel structure and interferes directly with the chromophore. Red waves indicate direct interaction between the analyte and the FP chromophore.
Cell Chemical Biology  , DOI: ( /j.chembiol )
Copyright © 2016 Elsevier Ltd Terms and Conditions