1. Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma 
D. Lardinois, MD, F.J. Jung, MD, I. Opitz, MD, K. Rentsch, MD, C. Latkoczy, MD, V. Vuong, PhD, Z. Varga, MD, V. Rousson, PhD, D. Günther, MD, S. Bodis, MD, R. Stahel, MD, W. Weder, MD 
The Journal of Thoracic and Cardiovascular Surgery 
Volume 131, Issue 3, Pages e3 (March 2006)
DOI: /j.jtcvs
Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

2. Figure 1
Platinum concentration in the tissue (chest wall) at different times after application in the chest cavity according to the mode of delivery.
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs )
Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

3. Figure 2
Platinum concentration in the serum at different times after application in the chest cavity according to the mode of delivery.
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs )
Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

4. Figure E1
Intraoperative view 10 days after implantation of the mesothelioma cells showing the retracted left lung before pneumonectomy and the tumor nodules disseminated on the pericardium, the hilus, and the chest wall.
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs )
Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

5. Figure E2
Intraoperative view showing the application of the gel cisplatin-fibrin sealant by use of the Spraypen with the Vivostat system after left pneumonectomy.
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs )
Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

6. Figure E3
Extensive acute tubular necrosis. Dilated tubules with necrotic detached epithelial cells, as well intraluminal calcifications, are shown. (Hematoxylin and eosin stain, original magnification 400×.)
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs )
Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

7. Figure E4
Cytoplasmic vacuolization of the subcortical tubules and fragmentation of brush border. (Periodic acid–Schiff stain, original magnification 400×.)
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs )
Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions