1. High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes 
Shelby A. Neal, M.D., Jason M. Franasiak, M.D., Eric J. Forman, M.D., H.C.L.D., Marie D. Werner, M.D., Scott J. Morin, M.D., Xin Tao, M.S., Nathan R. Treff, Ph.D., Richard T. Scott, M.D., H.C.L.D. 
Fertility and Sterility 
Volume 107, Issue 3, Pages e1 (March 2017)
DOI: /j.fertnstert
Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
Method for determination of biopsy DNA content as a surrogate for biopsy size. (A) Quantitative PCR-based mean threshold cycles (CT) from a 96-plex reaction were analyzed on samples with known numbers of cells (1, 2, 3, 4, 5, 10, 15, and 20) from a cultured cell line. (B) A standard curve was established, based on the cell number and average CT value. This curve was used to estimate the relative DNA content of each biopsy.
Fertility and Sterility  , e1DOI: ( /j.fertnstert )
Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

3. Figure 2
Pregnancy outcomes across quartiles of trophectoderm biopsy DNA content. The biopsy quartile with highest DNA content (Q4) demonstrated poorer outcomes across all measured outcomes.
Fertility and Sterility  , e1DOI: ( /j.fertnstert )
Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions