1. Respiration
C6H12O6 + 6O2 → 6CO2 + 6H2O

2. The Mitochondrion

3. Overview
10 (-2 Phosphorylation of glucose) (-2 for transport of 2NADH2 into the mitochondrion) = 6 2 28
Net production of ATP is 36 N.B. Anaerobic respiration only produces 2!

4. Exam style explanation of glycolysis
2ADP
2ATP P P
2ATP
2ADP
2ADP
2ATP
lysis
phosphorylation P P
Glucose 6C
Glucose diphosphate 6C
2 triose phosphates 3C
2 pyruvate 3C
2 ATPs are used
4 ATPs are produced
There is a net production of 2 ATPs
This happens in the cytoplasm!
Only the carbon atoms are shown!

5. The truth about glycolysis
2ADP
2ATP
NAD
NADH P P
2ATP
2ADP
2ADP
2ATP
NAD
NADH
lysis
phosphorylation P P
Glucose 6C
Glucose diphosphate 6C
2 triose phosphates 3C
2 pyruvate 3C
NADH is also produced
Each NADH can produce 3 more ATPs
Theoretically, up to 8 ATPs can be made in glycolysis
This happens in the cytoplasm!
Only the carbon atoms are shown!

6. Exam style explanation to the link reaction
CO2
3ATP
Accounts for 6ATP
2 Acetyl CoA 2C
2 pyruvate 3C
The ATP is produced via NADH
This happens in the mitochondria!

7. Exam style explanation to the Krebs Cycle
N.B. 12 ATPs per Kreb’s Cycle
2 turns of the cycle for each glucose = 24 ATPs
Plus 6 from the link reaction = 30 ATPs
2C Acetyl CoA 6C 4C
Accounts for 6ATP
ATP
3ATPs
KREBS CYCLE
Accounts for 2ATP
2ATPs
6ATP
CO2
Accounts for 4ATP
Accounts for 12ATP 5C
CO2

8. Main points Questions Glycolysis occurs in the cytoplasm
Glucose is phosphorylated using ATP
Glucose phosphate is split into two triose phosphates
2 ATPs used and 4 ATPs produced resulting in a net gain of 2 ATPs
Pyruvate is produced at the end of glycolysis
Pyruvate enters the mitochondria where it loses CO2 in the link reaction and producing NADH/More ATPs
This results in the production of Acetyl CoA (2C) which joins with a 4C compound to form a 6 carbon compound
This 6C compound is broken down to a 5C compound and then a 4C compound in the Kreb’s Cycle
Another 24 ATPs are produced.
Questions
Where does glycolysis occur?
Where does the Kreb’s Cycle occur?
Calculate the total (theoretical) number of ATPs that can be produced from one molecule of glucose.

9. Detail indicated by the IB Biology Guide