Presentation is loading. Please wait.

Presentation is loading. Please wait.

Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables  Larry Borish, MDa, Karen Schmaling,

Published byDerrick Atkinson Modified over 5 years ago

Similar presentations

Presentation on theme: "Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables  Larry Borish, MDa, Karen Schmaling,"— Presentation transcript:

1 Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables  Larry Borish, MDa, Karen Schmaling, PhDc, Jeannie D. DiClementi, PsyDa, Joanne Streib, BAb, Julie Negri, BSa, James F. Jones, MDb  Journal of Allergy and Clinical Immunology  Volume 102, Issue 2, Pages (August 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 IFN-α and TNF-α ELISA. PBMCs were obtained from normal subjects and individuals with CFS. Cells were lysed by means of repeat freeze-thawing, and lysate was assayed for IFN-α and TNF-α by using commercial ELISA kits. Data were normalized to number of PBMCs. Individual data points, as well as means and SEM, are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 IL-10 ELISA. IL-10 concentrations were determined by ELISA from normal subjects and subjects with CFS. Individual data points, as well as means and SEM, are shown. Data are expressed as mean picograms of IL-10 per 10 7 PBMCs. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Evaluation of IFN-α, TNF-α, and IL-10 at baseline and during self-reported exacerbations of CFS symptoms. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

5 Fig. 4 Evaluation of IFN-α, TNF-α, and IL-10 at baseline and during seasonal exposure to allergens in allergic individuals. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

6 Fig. 5 RT-PCR. PBMCs were obtained from subjects as described, and total RNA was isolated. After generating cDNA, preliminary PCR studies were performed to determine the optimal number of cycles to visualize samples in the logarithmic phase of expansion. PCR was subsequently performed for TNF-α and β-actin, and these PCR products from each individual were pooled and electrophoresed. Samples were electrophoretically transferred to nylon paper, hybridized to 32P-labeled nested probes for TNF-α and β-actin, and autoradiography was performed. Representative data are displayed. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

7 Fig. 6 RT-PCR was performed for TNF-α. After hybridization to a 32P-labeled nested probe and autoradiography, densitometric analysis was performed. Data were normalized to results observed with β-actin. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

Download ppt "Chronic fatigue syndrome: Identification of distinct subgroups on the basis of allergy and psychologic variables  Larry Borish, MDa, Karen Schmaling,"

Similar presentations

Double-blind placebo-controlled study of the efficacy of oral terfenadine in the treatment of chronic fatigue syndrome  Paul Steinberg, MDa, Bruce E.

Double-blind placebo-controlled study of the efficacy of oral terfenadine in the treatment of chronic fatigue syndrome  Paul Steinberg, MDa, Bruce E.
Immunopathogenesis of human gastrointestinal infection by Anisakis simplex  Victoria del Pozo, PhDa, Ignacio Arrieta, MDa, Teresa Tuñon, MD, PhDb, Isabel.

Immunopathogenesis of human gastrointestinal infection by Anisakis simplex  Victoria del Pozo, PhDa, Ignacio Arrieta, MDa, Teresa Tuñon, MD, PhDb, Isabel.
Glucocorticoids inhibit chemokine generation by human eosinophils

Glucocorticoids inhibit chemokine generation by human eosinophils
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice  Shinji.

Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice  Shinji.
Isolation and characterization of a clone encoding a major allergen (Bla g Bd90K) involved in IgE-mediated cockroach hypersensitivity  Ricki Helm, PhDa,

Isolation and characterization of a clone encoding a major allergen (Bla g Bd90K) involved in IgE-mediated cockroach hypersensitivity  Ricki Helm, PhDa,
The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,
The environmental pollutant pyrene induces the production of IL-4

The environmental pollutant pyrene induces the production of IL-4
Nerve growth factor is preformed in and activates human peripheral blood eosinophils  Abraham Solomon, MDa,b, Luigi Aloe, PhDc, Jacob Pe’er, MDa, Joseph.

Nerve growth factor is preformed in and activates human peripheral blood eosinophils  Abraham Solomon, MDa,b, Luigi Aloe, PhDc, Jacob Pe’er, MDa, Joseph.
Christine M. Braun, BA, Shau-Ku Huang, PhD, Gregory G

Christine M. Braun, BA, Shau-Ku Huang, PhD, Gregory G
Factors affecting the cytokine production of human T cells stimulated by different modes of activation  Yoshio Harada, MDa, Sumiko Watanabe, PhDa, Hans.

Factors affecting the cytokine production of human T cells stimulated by different modes of activation  Yoshio Harada, MDa, Sumiko Watanabe, PhDa, Hans.
Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis  Masatoshi Nakazawa, DVMa, Nakako Sugi, MDb, Hiroshi.

Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis  Masatoshi Nakazawa, DVMa, Nakako Sugi, MDb, Hiroshi.
Allergen-specific IgE production of committed B cells from allergic patients in vitro  Peter Steinberger, MSca, Barbara Bohlea, Franco di Padova, MDb,

Allergen-specific IgE production of committed B cells from allergic patients in vitro  Peter Steinberger, MSca, Barbara Bohlea, Franco di Padova, MDb,
Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis  Paul H. Ratner,

Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis  Paul H. Ratner,
Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with β2-adrenergic agonists  Elena Goleva, PhD, Annegret.

Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with β2-adrenergic agonists  Elena Goleva, PhD, Annegret.
Prostaglandin E2 control of T cell cytokine production is functionally related to the reduced lymphocyte proliferation in atopic dermatitis  Sai Chan,

Prostaglandin E2 control of T cell cytokine production is functionally related to the reduced lymphocyte proliferation in atopic dermatitis  Sai Chan,
Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles  David Diaz-Sanchez, PhD, Albert Tsien, MD, Adrian.

Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles  David Diaz-Sanchez, PhD, Albert Tsien, MD, Adrian.
Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk  Jun Ho Lee, PhD, Jie Wan Kim,

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk  Jun Ho Lee, PhD, Jie Wan Kim,
Badrul A. Chowdhury, MD, PhD 

Badrul A. Chowdhury, MD, PhD 
Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis  James.

Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis  James.
Conversion of the CD4+ T cell profile from TH2-dominant type to TH1-dominant type after varicella-zoster virus infection in atopic dermatitis  Takao Fujimura,

Conversion of the CD4+ T cell profile from TH2-dominant type to TH1-dominant type after varicella-zoster virus infection in atopic dermatitis  Takao Fujimura,

Similar presentations

Ads by Google