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Published byJari Hyttinen Modified over 5 years ago
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Inducing Hypoxemia in Healthy Humans: A Method for Intermittently Lowering Arterial Blood Oxygenation During Physiological Studies George W. Rodway, PhD, Leslie A. Hoffman, PhD, Frederick J. Tasota, MSN, Jigme M. Sethi, MD, Augustine M.K. Choi, MD, Stefan W. Ryter, PhD, Mark H. Sanders, MD Wilderness & Environmental Medicine Volume 19, Issue 3, Pages (September 2008) DOI: /07-WEME-LE-096.1 Copyright © 2008 Wilderness Medical Society Terms and Conditions
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Figure 1 Scheme of normoxic (□) and hypoxic (■) exposures for the habituation trial (60minutes room air), intermittent hypoxia (IH) session (6 hypoxic [FIO2 approximately 0.135] exposures for 10minutes each), and continuous hypoxia (CH) session (one 60-minute hypoxic [FIO2 approximately 0.135] exposure). Arrows indicate data collection periods during last 5minutes of normoxia prior to the day's initial hypoxia exposure, as well as during the last 5minutes of daily hypoxia exposure. Reprinted with permission from Rodway et al.9 Wilderness & Environmental Medicine , DOI: ( /07-WEME-LE-096.1) Copyright © 2008 Wilderness Medical Society Terms and Conditions
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Figure 2 SpO2: Mean of pre-exposure and last 5minutes of exposure by hypoxia profile and day (IH indicates intermittent hypoxia; CH, continuous hypoxia). Values are means ± SE. Wilderness & Environmental Medicine , DOI: ( /07-WEME-LE-096.1) Copyright © 2008 Wilderness Medical Society Terms and Conditions
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