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Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase 

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Presentation on theme: "Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase "— Presentation transcript:

1 Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase  Kittipong Maneechotesuwan, MD, PhD, Wuttichai Ekjiratrakul, MD, Kanda Kasetsinsombat, MSc, Adisak Wongkajornsilp, MD, PhD, Peter J. Barnes, DSc, FRS  Journal of Allergy and Clinical Immunology  Volume 126, Issue 4, Pages e1 (October 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Signaling pathways regulating IDO expression and activity. B, Flow of subjects through the study. IRF7, IFN-regulatory factor 7; T reg, regulatory T cell. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Sputum eosinophil percentages after budesonide (Bud) treatment in comparison with that after combined budesonide-simvastatin treatment (Bud+simvas). Results are expressed as medians (interquartile ranges), and Mann-Whitney P values are presented. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Gene expressions (mRNA) as indicated after inhaled budesonide (Bud; A) and combined budesonide-simvastatin treatment (Bud+simvas; B). Percentages of macrophages expressing IDO, NF-κB p52, and GITRL (C and D) are shown. Results are expressed as medians (interquartile ranges), and Mann-Whitney P values are presented. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 A, IDO activity after treatment with budesonide (Bud) and combined budesonide-simvastatin therapy (Bud+simvas). B and C, Correlation between IDO activity and sputum eosinophil count after budesonide (Fig 4, B) and combined budesonide-simvastatin treatment (Fig 4, C) are also shown. Results are expressed as medians (interquartile ranges), and Mann-Whitney P values are presented. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Association between IL-10 and IDO activity and sputum eosinophil count. Nuclear translocation of NF-κB p52 (A) and NF-κB p65 (B) Spearman rank correlation between sputum IL-10 and IDO activity (C and D) and absolute eosinophil counts (E and F) are shown. Results are expressed as medians (interquartile ranges), and Mann-Whitney P values are presented. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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