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Tumor Spread through Air Spaces Affects the Recurrence and Overall Survival in Patients with Lung Adenocarcinoma >2 to 3 cm  Chenyang Dai, MD, Huikang.

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Presentation on theme: "Tumor Spread through Air Spaces Affects the Recurrence and Overall Survival in Patients with Lung Adenocarcinoma >2 to 3 cm  Chenyang Dai, MD, Huikang."— Presentation transcript:

1 Tumor Spread through Air Spaces Affects the Recurrence and Overall Survival in Patients with Lung Adenocarcinoma >2 to 3 cm  Chenyang Dai, MD, Huikang Xie, MD, Hang Su, MD, Yunlang She, MD, Erjia Zhu, MD, Ziwen Fan, MD, Fangyu Zhou, MD, Yijiu Ren, MD, Dong Xie, MD, PhD, Hui Zheng, MD, PhD, Xiermaimaiti Kadeer, MD, Donglai Chen, MD, Liping Zhang, MD, Gening Jiang, MD, Chunyan Wu, MD, Chang Chen, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 7, Pages (July 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Morphologic features of tumor spread through air spaces including single cells (original magnification, ×40 [A] and ×200 [B]), micropapillary clusters (original magnification, ×40 [C] and ×200 [D]) and solid nests (original magnification, ×40 [E] and ×200 [F]). Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Recurrence-free survival (A) and overall survival (B) in patients with adenocarcinoma 3 cm or smaller stratified by spread through air spaces (STAS) in the study cohort. HR, hazard ratio; CI, confidence interval. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Recurrence-free survival and overall survival in patients with adenocarcinoma 2 cm or smaller (A are B) and larger than 2 to 3 cm (C and D) stratified by spread through air spaces (STAS) in the study cohort. HR, hazard ratio; CI, confidence interval. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

5 Supplementary Figure 1 Distance of tumor spread through air spaces from edge of main tumor measured by a ruler (A, C) and according to number of alveolar spaces (B, D). Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

6 Supplementary Figure 2 Distribution of the three types of tumor spread through air spaces according to the histologic pattern of adenocarcinoma in the study cohort (A) and the validation cohort (B). L, lepidic; A, acinar; P, papillary; MP, micropapillary; S, solid. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

7 Supplementary Figure 3 Recurrence–free survival (A) and overall survival (B) in patients with adenocarcinoma ≤ 3 cm stratified by STAS in the validation cohort. STAS, spread through air spaces. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

8 Supplementary Figure 4 Recurrence–free survival and overall survival in patients with adenocarcinoma ≤ 2 cm (A, B) and > 2–3 cm (C, D) stratified by STAS in the validation cohort. STAS, spread through air spaces. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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