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The Long and Short of MicroRNA

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1 The Long and Short of MicroRNA
Luke A. Yates, Chris J. Norbury, Robert J.C. Gilbert  Cell  Volume 153, Issue 3, Pages (April 2013) DOI: /j.cell Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 The Regulation of miRNA Function by Means of RNA Length
(A) Canonical maturation pathway of miRNA (see text for details). (B) Modification of the 3′ end of pre-miRNA by the untemplated addition of uridines catalyzed by cytoplasmic TUTs. Mono-uridylylation facilitates Dicer processing, whereas Lin28 binding and oligo-uridylylation are inhibitory. (C) Tuning of Dicer cut-site selection (shifted by 1–2 nt) by its binding partners allows the generation of specific isomiRs with altered target specificities. (D) Exonucleolytic 3′ trimming of the Ago-loaded mature miRNA alters the length and thus target specificity. Cell  , DOI: ( /j.cell ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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